Tenascin-C promotes tumor cell migration and metastasis through integrin α9β1–mediated YAP inhibition

Tenascin-C is an extracellular matrix molecule that drives progression of many types of human cancer, but the basis for its actions remains obscure. In this study, we describe a cell-autonomous signaling mechanism explaining how tenascin-C promotes cancer cell migration in the tumor microenvironment...

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Bibliographic Details
Main Authors: Sun, Z, Schwenzer, A, Rupp, T, Murdamoothoo, M, Vegliante, R, Lefebvre, O, Klein, A, Hussenet, T, Orend, G
Format: Journal article
Published: American Association for Cancer Research 2017