Characterising the contribution of Hrd1 complex components to the UPR: Implications for cancer cell survival
<p>The Hrd1 complex is a large multiprotein complex that spans the endoplasmic reticulum (ER) membrane with Hrd1 itself functioning as an E3 ligase in the endoplasmic reticulum associate degradation (ERAD) pathway in which unfolded and misfolded proteins are cleared from the ER in order to mai...
Main Author: | Evans, GT |
---|---|
Other Authors: | Christianson, J |
Format: | Thesis |
Language: | English |
Published: |
2023
|
Subjects: |
Similar Items
-
Dissecting the Distinct Tumor Microenvironments of HRD and HRP Ovarian Cancer: Implications for Targeted Therapies to Overcome PARPi Resistance in HRD Tumors and Refractoriness in HRP Tumors
by: Junjun Qiu, et al.
Published: (2024-10-01) -
SEL1L-HRD1 ER-associated degradation suppresses hepatocyte hyperproliferation and liver cancer
by: Asmita Bhattacharya, et al.
Published: (2022-10-01) -
CT-based radiomics predicts HRD score and HRD status in patients with ovarian cancer
by: Yujiao Wu, et al.
Published: (2025-01-01) -
SEL1L-HRD1 interaction is required to form a functional HRD1 ERAD complex
by: Liangguang Leo Lin, et al.
Published: (2024-02-01) -
Functional organisation of the Hrd1 ubiquitin ligase complex and its role in ERAD
by: Schulz, J
Published: (2013)