Palladium catalysed elaboration of codeine and morphine
Palladium catalysed coupling reactions of 6-O-tert-butyldimethylsilyl-1-bromocodeine and 6-O-tert-butyldimethylsilyl-3-trifluoromethylsulfonylmorphine allow a range of substituted analogues of codeine in the 1-position and morphine in the 3-position to be efficiently and selectively prepared.
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2001
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