Identification of human-to-human transmissibility factors in PB2 proteins of influenza A by large-scale mutual information analysis

Background: The identification of mutations that confer unique properties to a pathogen, such as host range, is of fundamental importance in the fight against disease. This paper describes a novel method for identifying amino acid sites that distinguish specific sets of protein sequences, by compara...

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Bibliographic Details
Main Authors: Miotto, O, Heiny, A, Tan, T, August, J, Brusic, V
Format: Journal article
Language:English
Published: 2007