The extracellular chaperone clusterin potently inhibits human lysozyme amyloid formation by interacting with prefibrillar species.

The extracellular chaperone clusterin potently inhibits human lysozyme amyloid formation by interacting with prefibrillar species.

We have studied the effects of the extracellular molecular chaperone, clusterin, on the in vitro aggregation of mutational variants of human lysozyme, including one associated with familial amyloid disease. The aggregation of the amyloidogenic variant I56T is inhibited significantly at clusterin to...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Kumita, JR, Poon, S, Caddy, G, Hagan, C, Dumoulin, M, Yerbury, J, Stewart, E, Robinson, C, Wilson, MR, Dobson, C
Μορφή:	Journal article
Γλώσσα:	English
Έκδοση:	2007

Παρόμοια τεκμήρια

Rationalising lysozyme amyloidosis: insights from the structure and solution dynamics of T70N lysozyme.
ανά: Johnson, R, κ.ά.
Έκδοση: (2005)

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ανά: Patricia Yuste-Checa, κ.ά.
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The significance of the location of mutations for the native-state dynamics of human lysozyme
ανά: Ahn, M, κ.ά.
Έκδοση: (2016)

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ανά: Abigail K. Elias, κ.ά.
Έκδοση: (2022-10-01)

Molecular mechanisms at the basis of the protective effect exerted by EPPS on neurodegeneration induced by prefibrillar amyloid oligomers
ανά: Beatrice Zarrilli, κ.ά.
Έκδοση: (2024-11-01)

Expression and purification of chaperone-active recombinant clusterin.
ανά: Rebecca A Dabbs, κ.ά.
Έκδοση: (2014-01-01)

A nanobody binding to non-amyloidogenic regions of the protein human lysozyme enhances partial unfolding but inhibits amyloid fibril formation.
ανά: De Genst, E, κ.ά.
Έκδοση: (2013)

A non-natural variant of human lysozyme (I59T) mimics the in vitro behaviour of the I56T variant that is responsible for a form of familial amyloidosis.
ανά: Hagan, C, κ.ά.
Έκδοση: (2010)

Engineering a camelid antibody fragment that binds to the active site of human lysozyme and inhibits its conversion into amyloid fibrils.
ανά: Chan, P, κ.ά.
Έκδοση: (2008)

A camelid antibody fragment inhibits the formation of amyloid fibrils by human lysozyme.
ανά: Dumoulin, M, κ.ά.
Έκδοση: (2003)

Impact of the native-state stability of human lysozyme variants on protein secretion by Pichia pastoris.
ανά: Kumita, JR, κ.ά.
Έκδοση: (2006)

Instability, unfolding and aggregation of human lysozyme variants underlying amyloid fibrillogenesis.
ανά: Booth, DR, κ.ά.
Έκδοση: (1997)

Pathway Dependence of the Formation and Development of Prefibrillar Aggregates in Insulin B Chain
ανά: Yuki Yoshikawa, κ.ά.
Έκδοση: (2022-06-01)

Formation and seeding of amyloid fibrils from wild-type hen lysozyme and a peptide fragment from the beta-domain.
ανά: Krebs, MR, κ.ά.
Έκδοση: (2000)

Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers
ανά: Rasool Suhail, κ.ά.
Έκδοση: (2007-09-01)

BIOT 243-Biophysical study of the aggregation of human lysozyme into amyloid fibrils
ανά: Dhulesia, A, κ.ά.
Έκδοση: (2008)

Investigation of non-covalent interactions of amyloidogenic human lysozyme variants and camelid antibodies
ανά: Caddy, G, κ.ά.
Έκδοση: (2002)

The conformation of lysozyme in solution
ανά: Dobson, C, κ.ά.
Έκδοση: (1975)

Association of clusterin with the BRI2-derived amyloid molecules ABri and ADan
ανά: Agueda Rostagno, κ.ά.
Έκδοση: (2021-10-01)

Insights into amyloid fibril formation from mass spectrometry.
ανά: Caddy, G, κ.ά.
Έκδοση: (2006)

Clusterin is required for β-Amyloid toxicity in human iPSC-derived neurons
ανά: Robbins, J, κ.ά.
Έκδοση: (2018)

Interaction of the molecular chaperone alpha B-crystallin with alpha-synuclein: Effects on amyloid fibril formation and chaperone activity
ανά: Rekas, A, κ.ά.
Έκδοση: (2004)

Interaction of the molecular chaperone alphaB-crystallin with alpha-synuclein: effects on amyloid fibril formation and chaperone activity.
ανά: Rekas, A, κ.ά.
Έκδοση: (2004)

Conformational dynamics and protein unfolding in lysozyme amyloidosis
ανά: Sunde, M, κ.ά.
Έκδοση: (1999)

Apolipoprotein E and clusterin inhibit the early phase of amyloid-β aggregation in an in vitro model of cerebral amyloid angiopathy
ανά: Yoshinori Endo, κ.ά.
Έκδοση: (2019-01-01)

Conformation dependent monoclonal antibodies distinguish different replicating strains or conformers of prefibrillar Aβ oligomers
ανά: Yeung Stephen, κ.ά.
Έκδοση: (2010-12-01)

Effects of model membranes on lysozyme amyloid aggregation
ανά: Burrelli Annaclaudia, κ.ά.
Έκδοση: (2023-08-01)

Reduced global cooperativity is a common feature underlying the amyloidogenicity of pathogenic lysozyme mutations.
ανά: Dumoulin, M, κ.ά.
Έκδοση: (2005)

Kinetic consequences of the removal of a disulfide bridge on the folding of hen lysozyme.
ανά: Eyles, S, κ.ά.
Έκδοση: (1994)

Characterisation of the dominant oxidative folding intermediate of hen lysozyme.
ανά: van den Berg, B, κ.ά.
Έκδοση: (1999)

BACE1 regulates expression of Clusterin in astrocytes for enhancing clearance of β-amyloid peptides
ανά: John Zhou, κ.ά.
Έκδοση: (2023-05-01)

Structure of hen lysozyme in solution.
ανά: Smith, L, κ.ά.
Έκδοση: (1993)

Molecular recycling within amyloid fibrils.
ανά: Carulla, N, κ.ά.
Έκδοση: (2005)

The origin of the alpha-domain intermediate in the folding of hen lysozyme.
ανά: Matagne, A, κ.ά.
Έκδοση: (1998)

Analysis of the native structure, stability and aggregation of biotinylated human lysozyme.
ανά: Minkoo Ahn, κ.ά.
Έκδοση: (2012-01-01)

Amyloid β peptide promotes lysosomal degradation of clusterin via sortilin in hippocampal primary neurons
ανά: Yunling Wang, κ.ά.
Έκδοση: (2017-07-01)

Molecular Docking of Monomethine Cyanine Dyes to Lysozyme Amyloid Fibrils
ανά: Olga Zhytniakivska, κ.ά.
Έκδοση: (2022-09-01)

Inhibition of Lysozyme Amyloid Fibrillation by Silybin Diastereoisomers: The Effects of Stereochemistry
ανά: Xuanyu Chen, κ.ά.
Έκδοση: (2021-01-01)

Carnosine's effect on amyloid fibril formation and induced cytotoxicity of lysozyme.
ανά: Josephine W Wu, κ.ά.
Έκδοση: (2013-01-01)

Oxidative refolding of amyloidogenic variants of human lysozyme.
ανά: Wain, R, κ.ά.
Έκδοση: (2005)