The extracellular chaperone clusterin potently inhibits human lysozyme amyloid formation by interacting with prefibrillar species.

The extracellular chaperone clusterin potently inhibits human lysozyme amyloid formation by interacting with prefibrillar species.

We have studied the effects of the extracellular molecular chaperone, clusterin, on the in vitro aggregation of mutational variants of human lysozyme, including one associated with familial amyloid disease. The aggregation of the amyloidogenic variant I56T is inhibited significantly at clusterin to...

书目详细资料
Main Authors:	Kumita, JR, Poon, S, Caddy, G, Hagan, C, Dumoulin, M, Yerbury, J, Stewart, E, Robinson, C, Wilson, MR, Dobson, C
格式:	Journal article
语言:	English
出版:	2007

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