Phosphatidylinositol 4,5-bisphosphate clusters act as molecular beacons for vesicle recruitment.
Synaptic-vesicle exocytosis is mediated by the vesicular Ca(2+) sensor synaptotagmin-1. Synaptotagmin-1 interacts with the SNARE protein syntaxin-1A and acidic phospholipids such as phosphatidylinositol 4,5-bisphosphate (PIP2). However, it is unclear how these interactions contribute to triggering m...
Main Authors: | , , , , , , , , , , , , , |
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Format: | Journal article |
Language: | English |
Published: |
2013
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