Phosphatidylinositol 4,5-bisphosphate clusters act as molecular beacons for vesicle recruitment.

Phosphatidylinositol 4,5-bisphosphate clusters act as molecular beacons for vesicle recruitment.

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Synaptic-vesicle exocytosis is mediated by the vesicular Ca(2+) sensor synaptotagmin-1. Synaptotagmin-1 interacts with the SNARE protein syntaxin-1A and acidic phospholipids such as phosphatidylinositol 4,5-bisphosphate (PIP2). However, it is unclear how these interactions contribute to triggering m...

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Bibliographic Details
Main Authors:	Honigmann, A, van den Bogaart, G, Iraheta, E, Risselada, H, Milovanovic, D, Mueller, V, Müllar, S, Diederichsen, U, Fasshauer, D, Grubmüller, H, Hell, S, Eggeling, C, Kühnel, K, Jahn, R
Format:	Journal article
Language:	English
Published:	2013

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