Polyunsaturated liposomes are antiviral against hepatitis B and C viruses and HIV by decreasing cholesterol levels in infected cells.

Polyunsaturated liposomes are antiviral against hepatitis B and C viruses and HIV by decreasing cholesterol levels in infected cells.

The pressing need for broad-spectrum antivirals could be met by targeting host rather than viral processes. Cholesterol biosynthesis within the infected cell is one promising target for a large number of viral systems, including hepatitis C virus (HCV), hepatitis B virus (HBV) and HIV. Liposomes dev...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Pollock, S, Nichita, N, Böhmer, A, Radulescu, C, Dwek, R, Zitzmann, N
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	National Academy of Sciences 2010

Eitemau Tebyg

Cholesterol level lowering liposomes
gan: Pollock, S, et al.
Cyhoeddwyd: (2012)

Liposome treatment of viral infections
gan: Dwek, R, et al.
Cyhoeddwyd: (2011)

Endoplasmic reticulum targeting liposomes
gan: Pollock, S, et al.
Cyhoeddwyd: (2011)

Cholesterol depletion of hepatoma cells impairs hepatitis B virus envelopment by altering the topology of the large envelope protein
gan: Dorobantu, C, et al.
Cyhoeddwyd: (2011)

Study of the mechanism of antiviral action of iminosugar derivatives against bovine viral diarrhea virus.
gan: Durantel, D, et al.
Cyhoeddwyd: (2001)

N-Butyldeoxynojirimycin is a broadly effective anti-HIV therapy significantly enhanced by targeted liposome delivery.
gan: Pollock, S, et al.
Cyhoeddwyd: (2008)

Antiviral effects of amantadine and iminosugar derivatives against hepatitis C virus.
gan: Steinmann, E, et al.
Cyhoeddwyd: (2007)

Uptake and trafficking of liposomes to the endoplasmic reticulum
gan: Pollock, S, et al.
Cyhoeddwyd: (2010)

Glycobiology against viruses: Antiviral drug discovery
gan: Zitzmann, N, et al.
Cyhoeddwyd: (2006)

The bovine viral diarrhoea virus: a model for the study of antiviral molecules interfering with N-glycosylation and folding of envelope glycoprotein
gan: Durantel, D, et al.
Cyhoeddwyd: (2015)

Hepatitis B virus requires intact caveolin-1 function for productive infection in HepaRG cells.
gan: Macovei, A, et al.
Cyhoeddwyd: (2010)

Antiviral effect of N-butyldeoxynojirimycin against bovine viral diarrhea virus correlates with misfolding of E2 envelope proteins and impairment of their association into E1-E2 heterodimers.
gan: Branza-Nichita, N, et al.
Cyhoeddwyd: (2001)

Targeting the host ER alpha glucosidases I and II as antiviral therapy
gan: Branza-Nichita, N, et al.
Cyhoeddwyd: (2007)

Liposome-mediated delivery of iminosugars enhances efficacy against dengue virus in vivo.
gan: Miller, J, et al.
Cyhoeddwyd: (2012)

Mechanisms of antiviral activity of iminosugars against dengue virus
gan: Miller, JL, et al.
Cyhoeddwyd: (2018)

Treatment of hepatitis B virus-infected cells with alpha-glucosidase inhibitors results in production of virions with altered molecular composition and infectivity.
gan: Lazar, C, et al.
Cyhoeddwyd: (2007)

Virus morphogenesis and viral entry as alternative targets for novel hepatitis C antivirals
gan: Chapel, C, et al.
Cyhoeddwyd: (2006)

Antiviral effect of alpha-glucosidase inhibitors on viral morphogenesis and binding properties of hepatitis C virus-like particles.
gan: Chapel, C, et al.
Cyhoeddwyd: (2006)

Iminosugar antivirals: the therapeutic sweet spot
gan: Alonzi, D, et al.
Cyhoeddwyd: (2017)

Effects of interferon, ribavirin, and iminosugar derivatives on cells persistently infected with noncytopathic bovine viral diarrhea virus.
gan: Durantel, D, et al.
Cyhoeddwyd: (2004)

Host-targeting oral antiviral drugs to prevent pandemics
gan: Dwek, RA, et al.
Cyhoeddwyd: (2022)

Targeting a host process as an antiviral approach against dengue virus
gan: Sayce, A, et al.
Cyhoeddwyd: (2010)

Use of castanospermine and substituted-castonospermine compounds for treating hepatitis virus infections
gan: Jacob, G, et al.
Cyhoeddwyd: (2001)

Protein-protein interactions: modeling the hepatitis C virus ion channel p7.
gan: Patargias, G, et al.
Cyhoeddwyd: (2005)

The Hepatitis C Virus E2p7 localization and topology in a recombinant system
gan: Popescu, C, et al.
Cyhoeddwyd: (2009)

Antiviral effects of an iminosugar derivative on flavivirus infections.
gan: Wu, S, et al.
Cyhoeddwyd: (2002)

Role of N-glycan trimming in the folding and secretion of the pestivirus protein E(rns)
gan: Branza-Nichita, N, et al.
Cyhoeddwyd: (2004)

The pestivirus E(rns) glycoprotein interacts with E2 in both infected cells and mature virions.
gan: Lazar, C, et al.
Cyhoeddwyd: (2003)

Iminosugars in combination with interferon and ribavirin permanently eradicate noncytopathic bovine viral diarrhea virus from persistently infected cells.
gan: Woodhouse, S, et al.
Cyhoeddwyd: (2008)

Bypass of quality control in protein folding pathways induces specific misfolding of HIV envelope V2 loop: implications for iminosugars as antivirals
gan: Spiro, S, et al.
Cyhoeddwyd: (2014)

Conservation of hydrophobicity within viral envelope glycoproteins reveals a putative hepatitis C virus fusion peptide
gan: Taylor, A, et al.
Cyhoeddwyd: (2009)

Clinical diagnosis of hepatic fibrosis using human serum APOL1 as biomarker
gan: Gangadharan, B, et al.
Cyhoeddwyd: (2012)

Glycyrrhizin as antiviral agent against Hepatitis C Virus
gan: Ashfaq Usman A, et al.
Cyhoeddwyd: (2011-07-01)

Imino sugars inhibit the formation and secretion of bovine viral diarrhea virus, a pestivirus model of hepatitis C virus: Implications for the development of broad spectrum anti-hepatitis virus agents
gan: Zitzmann, N, et al.
Cyhoeddwyd: (1999)

The Effect of Antiviral Therapy on Serum Cholesterol Levels in Chronic Hepatitis C
Cyhoeddwyd: (2011-09-01)

Clinical diagnosis of hepatic fibrosis using a novel panel of human serum protein biomarkers
gan: Gangadharan, B, et al.
Cyhoeddwyd: (2008)

Efficacy decrease of antiviral agents when administered to ongoing hepatitis C virus infections in cell culture
gan: Carlos García-Crespo, et al.
Cyhoeddwyd: (2022-08-01)

Clinical diagnosis of hepatic fibrosis using a novel panel of low abundant human plasma protein biomarkers
gan: Gangadharan, B, et al.
Cyhoeddwyd: (2010)

Strain-specific antiviral activity of iminosugars against human influenza A viruses.
gan: Hussain, S, et al.
Cyhoeddwyd: (2015)

The expression of hepatic carboxypeptidase E is decreased in patients with cholesterol gallstone
gan: Shu-Long Dai, et al.
Cyhoeddwyd: (2015-01-01)