The virtual assay software for human in silico drug trials to augment drug cardiac testing
Prediction of drug effects on the heart still represents a challenge in drug development, given potential adverse outcomes. Computer modelling and simulations of the human heart offer a powerful technology to augment existing animal and clinical methodologies. Here we describe the translation proces...
Главные авторы: | Passini, E, Zhou, X, Trovato, C, Britton, OJ, Bueno-Orovio, A, Rodriguez, B |
---|---|
Формат: | Journal article |
Язык: | English |
Опубликовано: |
Elsevier
2020
|
Схожие документы
-
Drug‐induced shortening of the electromechanical window is an effective biomarker for in silico prediction of clinical risk of arrhythmias
по: Passini, E, и др.
Опубликовано: (2019) -
Blinded in silico drug trial reveals the minimum set of ion channels for torsades de pointes risk assessment
по: Zhou, X, и др.
Опубликовано: (2020) -
Cross clinical-experimental-computational qualification of in silico drug trials on human cardiac purkinje cells for proarrhythmia risk prediction
по: Cristian Trovato, и др.
Опубликовано: (2022-10-01) -
Human in silico drug trials demonstrate higher accuracy than animal models in predicting clinical pro-arrhythmic cardiotoxicity
по: Passini, E, и др.
Опубликовано: (2017) -
P511 In silico trials in human ventricular and purkinje cell models predict safety and efficacy of 10 antiarrhythmic drugs
по: Trovato, C, и др.
Опубликовано: (2017)