Cytotoxic T-cell antagonism in HIV-1
The cytotoxic T-cell (CTL) response to human immunodeficiency virus Type 1 (HIV-1) is vigorous and sustained, but despite this, the virus persists. Natural variation arising within CTL epitopes may affect CTL recognition of infected targets and allow viral escape. Some of these variant epitopes appe...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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1996
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| _version_ | 1797103460545462272 |
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| author | Klenerman, P Phillips, R McMichael, A |
| author_facet | Klenerman, P Phillips, R McMichael, A |
| author_sort | Klenerman, P |
| collection | OXFORD |
| description | The cytotoxic T-cell (CTL) response to human immunodeficiency virus Type 1 (HIV-1) is vigorous and sustained, but despite this, the virus persists. Natural variation arising within CTL epitopes may affect CTL recognition of infected targets and allow viral escape. Some of these variant epitopes appear to engage T-cell receptors but fail to activate the CTL normally. This can interfere with recognition of the unmutated epitope - a phenomenon known as T-cell antagonism. We discuss the evidence for this in HIV-1 using CTL and epitope variants derived from infected donors, and discuss its possible relevance in vivo. |
| first_indexed | 2024-03-07T06:20:26Z |
| format | Journal article |
| id | oxford-uuid:f2892f70-d7bd-4cae-b5bb-8e336678f95b |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:20:26Z |
| publishDate | 1996 |
| record_format | dspace |
| spelling | oxford-uuid:f2892f70-d7bd-4cae-b5bb-8e336678f95b2022-03-27T12:04:34ZCytotoxic T-cell antagonism in HIV-1Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f2892f70-d7bd-4cae-b5bb-8e336678f95bEnglishSymplectic Elements at Oxford1996Klenerman, PPhillips, RMcMichael, AThe cytotoxic T-cell (CTL) response to human immunodeficiency virus Type 1 (HIV-1) is vigorous and sustained, but despite this, the virus persists. Natural variation arising within CTL epitopes may affect CTL recognition of infected targets and allow viral escape. Some of these variant epitopes appear to engage T-cell receptors but fail to activate the CTL normally. This can interfere with recognition of the unmutated epitope - a phenomenon known as T-cell antagonism. We discuss the evidence for this in HIV-1 using CTL and epitope variants derived from infected donors, and discuss its possible relevance in vivo. |
| spellingShingle | Klenerman, P Phillips, R McMichael, A Cytotoxic T-cell antagonism in HIV-1 |
| title | Cytotoxic T-cell antagonism in HIV-1 |
| title_full | Cytotoxic T-cell antagonism in HIV-1 |
| title_fullStr | Cytotoxic T-cell antagonism in HIV-1 |
| title_full_unstemmed | Cytotoxic T-cell antagonism in HIV-1 |
| title_short | Cytotoxic T-cell antagonism in HIV-1 |
| title_sort | cytotoxic t cell antagonism in hiv 1 |
| work_keys_str_mv | AT klenermanp cytotoxictcellantagonisminhiv1 AT phillipsr cytotoxictcellantagonisminhiv1 AT mcmichaela cytotoxictcellantagonisminhiv1 |