Cis-acting sequences regulating expression of the human alpha-globin cluster lie within constitutively open chromatin.
Current models suggest that tissue-specific genes are arranged in discrete, independently controlled segments of chromatin referred to as regulatory domains. Transition from a closed to open chromatin structure may be an important step in the regulation of gene expression. To determine whether the h...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1992
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