Cis-acting sequences regulating expression of the human alpha-globin cluster lie within constitutively open chromatin.

Cis-acting sequences regulating expression of the human alpha-globin cluster lie within constitutively open chromatin.

Current models suggest that tissue-specific genes are arranged in discrete, independently controlled segments of chromatin referred to as regulatory domains. Transition from a closed to open chromatin structure may be an important step in the regulation of gene expression. To determine whether the h...

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Bibliografiske detaljer
Main Authors:	Vyas, P, Vickers, M, Simmons, D, Ayyub, H, Craddock, C, Higgs, D
Format:	Journal article
Sprog:	English
Udgivet:	1992

Lignende værker

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A revised model for promoter competition based on multi-way chromatin interactions at the α-globin locus
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Activation of the alpha-globin gene expression correlates with dramatic upregulation of nearby non-globin genes and changes in local and large-scale chromatin spatial structure
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