Cis-acting sequences regulating expression of the human alpha-globin cluster lie within constitutively open chromatin.
Current models suggest that tissue-specific genes are arranged in discrete, independently controlled segments of chromatin referred to as regulatory domains. Transition from a closed to open chromatin structure may be an important step in the regulation of gene expression. To determine whether the h...
Κύριοι συγγραφείς: | Vyas, P, Vickers, M, Simmons, D, Ayyub, H, Craddock, C, Higgs, D |
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Μορφή: | Journal article |
Γλώσσα: | English |
Έκδοση: |
1992
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Παρόμοια τεκμήρια
Παρόμοια τεκμήρια
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Contrasting effects of alpha and beta globin regulatory elements on chromatin structure may be related to their different chromosomal environments.
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De novo deletion within the telomeric region flanking the human alpha globin locus as a cause of alpha thalassaemia.
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Molecular rearrangements of the human alpha-globin gene cluster.
ανά: Higgs, D, κ.ά.
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Alpha-thalassemia caused by a large (62 kb) deletion upstream of the human alpha globin gene cluster.
ανά: Hatton, C, κ.ά.
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Conservation of position and sequence of a novel, widely expressed gene containing the major human alpha-globin regulatory element.
ανά: Vyas, P, κ.ά.
Έκδοση: (1995)