Cis-acting sequences regulating expression of the human alpha-globin cluster lie within constitutively open chromatin.

Cis-acting sequences regulating expression of the human alpha-globin cluster lie within constitutively open chromatin.

Current models suggest that tissue-specific genes are arranged in discrete, independently controlled segments of chromatin referred to as regulatory domains. Transition from a closed to open chromatin structure may be an important step in the regulation of gene expression. To determine whether the h...

Bibliográfalaš dieđut
Váldodahkkit:	Vyas, P, Vickers, M, Simmons, D, Ayyub, H, Craddock, C, Higgs, D
Materiálatiipa:	Journal article
Giella:	English
Almmustuhtton:	1992

Geahča maid

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Molecular rearrangements of the human alpha-globin gene cluster.
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Dahkki: Hatton, C, et al.
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Conservation of position and sequence of a novel, widely expressed gene containing the major human alpha-globin regulatory element.
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Analysis of the human alpha-globin gene cluster in transgenic mice.
Dahkki: Sharpe, J, et al.
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Sp1 functions in a chromatin-dependent manner to augment human alpha-globin promoter activity.
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Dahkki: Viprakasit, V, et al.
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Dahkki: Sharpe, J, et al.
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Dahkki: De Gobbi, M, et al.
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The mouse alpha-globin locus regulatory element.
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A large deletion in the human alpha-globin cluster caused by a replication error is associated with an unexpectedly mild phenotype.
Dahkki: Rugless, M, et al.
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Long-range regulation of alpha globin gene expression during erythropoiesis.
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Deletion of the alpha-globin gene cluster as a cause of acquired alpha-thalassemia in myelodysplastic syndrome.
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Almmustuhtton: (2009)

Role of upstream DNase I hypersensitive sites in the regulation of human alpha globin gene expression.
Dahkki: Sharpe, J, et al.
Almmustuhtton: (1993)

The role of the polycomb complex in silencing alpha-globin gene expression in nonerythroid cells.
Dahkki: Garrick, D, et al.
Almmustuhtton: (2008)

Identification of mutations in a trans-acting factor with different effects on alpha and beta globin expression.
Dahkki: Viprakasit, V, et al.
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Identification of mutations in a trans-acting factor with different effects on alpha and beta globin expression.
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EFFECT OF CIS ACTING POTENTIAL REGULATORS IN THE ß GLOBIN GENE CLUSTER ON THE PRODUCTION OF HBF IN THALASSEMIA PATIENTS
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The role of histone deacetylases in repressing alpha-globin gene expression in non-erythroid cells.
Dahkki: Garrick, D, et al.
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Does Transcription of Remote alpha-Globin Regulatory Elements Affect Their Function?
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Expression of the human alpha-globin cluster in the absence of the major regulatory element Mcs-R2
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Dahkki: Anguita, E, et al.
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Dahkki: Oudelaar, A, et al.
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The structure of a human alpha-globin pseudogene and its relationship to alpha-globin gene duplication.
Dahkki: Proudfoot, N, et al.
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