Population-specific risk of type 2 diabetes conferred by HNF4A P2 promoter variants: a lesson for replication studies.

Population-specific risk of type 2 diabetes conferred by HNF4A P2 promoter variants: a lesson for replication studies.

OBJECTIVE: Single nucleotide polymorphisms (SNPs) in the P2 promoter region of HNF4A were originally shown to be associated with predisposition for type 2 diabetes in Finnish, Ashkenazi, and, more recently, Scandinavian populations, but they generated conflicting results in additional populations. W...

書目詳細資料
Main Authors:	Barroso, I, Luan, J, Wheeler, E, Whittaker, P, Wasson, J, Zeggini, E, Weedon, M, Hunt, S, Venkatesh, R, Frayling, T, Delgado, M, Neuman, R, Zhao, J, Sherva, R, Glaser, B, Walker, M, Hitman, G, McCarthy, M, Hattersley, A, Permutt, M, Wareham, N, Deloukas, P
格式:	Journal article
語言:	English
出版:	2008

相似書籍

A large-scale association analysis of common variation of the HNF1alpha gene with type 2 diabetes in the U.K. Caucasian population.
由: Weedon, M, et al.
出版: (2005)

Common variants in WFS1 confer risk of type 2 diabetes.
由: Sandhu, MS, et al.
出版: (2007)

Common variants of the hepatocyte nuclear factor-4alpha P2 promoter are associated with type 2 diabetes in the U.K. population.
由: Weedon, M, et al.
出版: (2004)

Association analysis of 6,736 U.K. subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk.
由: Groves, C, et al.
出版: (2006)

Interrogating type 2 diabetes genome-wide association data using a biological pathway-based approach.
由: Perry, JR, et al.
出版: (2009)

The role of the HNF4alpha enhancer in type 2 diabetes.
由: Mitchell, S, et al.
出版: (2002)

The role of the HNF4α enhancer in type 2 diabetes variants of the HNF4α enhancer are not a common cause of susceptibility to type 2 diabetes
由: Mitchell, S, et al.
出版: (2002)

Functional variation in VEGF is not associated with type 2 diabetes in a United Kingdom Caucasian population.
由: Freathy, R, et al.
出版: (2006)

Large scale case-control and family-based analyses of TCF7L2 variants in > 6000 UK subjects demonstrates an almost two-fold difference in relative risk between homozygote classes
由: Groves, C, et al.
出版: (2006)

No evidence of association of ENPP1 variants with type 2 diabetes or obesity in a study of 8,089 U.K. Caucasians.
由: Weedon, M, et al.
出版: (2006)

Combining information from common type 2 diabetes risk polymorphisms improves disease prediction
由: Weedon, M, et al.
出版: (2006)

Combining information from common type 2 diabetes risk polymorphisms improves disease prediction.
由: Weedon, M, et al.
出版: (2006)

Large-scale association studies of candidate genes and their interactions in Type 2 diabetes
由: Zeggini, E, et al.
出版: (2004)

Common variation in the LMNA gene increases susceptibility to type 2 diabetes
由: Owen, K, et al.
出版: (2006)

The functional "KL-VS" variant of KLOTHO is not associated with type 2 diabetes in 5028 UK Caucasians
由: Freathy, R, et al.
出版: (2006)

Type 2 diabetes transcription factor 7-like 2 (TCF7L2) risk alleles reduce beta-cell function and increase birth weight
由: Freathy, R, et al.
出版: (2007)

Common variations in the ALMS1 gene do not contribute to susceptibility to type 2 diabetes in a large white UK population.
由: Patel, S, et al.
出版: (2006)

Detailed investigation of the role of common and low-frequency WFS1 variants in type 2 diabetes risk.
由: Fawcett, K, et al.
出版: (2010)

Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk.
由: Lango, H, et al.
出版: (2008)

Low frequency variants in the exons only encoding isoform A of HNF1A do not contribute to susceptibility to type 2 diabetes.
由: Bahram Jafar-Mohammadi, et al.
出版: (2009-08-01)

Low frequency variants in the exons only encoding isoform A of HNF1A do not contribute to susceptibility to Type 2 diabetes
由: Jafar-Mohammadi, B, et al.
出版: (2009)

Low frequency variants in the exons only encoding isoform A of HNF1A do not contribute to susceptibility to type 2 diabetes.
由: Jafar-Mohammadi, B, et al.
出版: (2009)

A role for coding functional variants in HNF4A in type 2 diabetes susceptibility
由: Jafar-Mohammadi, B, et al.
出版: (2011)

A role for coding functional variants in HNF4A in type 2 diabetes susceptibility.
由: Jafar-Mohammadi, B, et al.
出版: (2011)

Large-scale type 2 diabetes association analysis of low-frequency nonsynonymous coding variants in the HNF4A gene including up to 17,600 individuals
由: Mohammadi, B, et al.
出版: (2008)

Examining the relationships between the Pro12Ala variant in PPARG and Type 2 diabetes-related traits in UK samples.
由: Zeggini, E, et al.
出版: (2005)

Combining information from common type 2 diabetes risk polymorphisms improves disease prediction.
由: Michael N Weedon, et al.
出版: (2006-10-01)

Sequencing PDX1 (insulin promoter factor 1) in 1788 UK individuals found 5% had a low frequency coding variant, but these variants are not associated with Type 2 diabetes.
由: Edghill, E, et al.
出版: (2011)

Role of the D76N polymorphism of insulin promoter factor-1 in predisposing to Type 2 diabetes.
由: Owen, K, et al.
出版: (2004)

Role of low frequency variants in HNF1A exons 8-10 encoding hepatocyte nuclear factor-1 alpha isoform A to susceptibility to Type 2 diabetes
由: Jafar-Mohammadi, B, et al.
出版: (2010)

Lipoprotein composition in HNF1A-MODY: differentiating between HNF1A-MODY and type 2 diabetes.
由: McDonald, T, et al.
出版: (2012)

Fine-mapping type 2 diabetes causal variants on chromosome 9p21 in 2000 UK cases and 3000 unselected controls
由: Morris, A, et al.
出版: (2008)

Association studies of insulin receptor substrate 1 gene (IRS1) variants in type 2 diabetes samples enriched for family history and early age of onset.
由: Zeggini, E, et al.
出版: (2004)

Assessment of the role of common genetic variation in the transient neonatal diabetes mellitus (TNDM) region in type 2 diabetes: a comparative genomic and tagging single nucleotide polymorphism approach.
由: Gloyn, A, et al.
出版: (2006)

Large-scale studies of the association between variation at the TNF/LTA locus and susceptibility to type 2 diabetes.
由: Zeggini, E, et al.
出版: (2005)

Assessment of the role of genetic variation in the transient neonatal diabetes (TNDM) region on chromosome 6q24 in type 2 diabetes: a comparative genomic and haplotype approach
由: Gloyn, A, et al.
出版: (2005)

Circulating beta-carotene levels and type 2 diabetes-cause or effect?
由: Perry, JR, et al.
出版: (2009)

Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data.
由: Timpson, N, et al.
出版: (2009)

Extended analysis of genome-wide scans provides clues about novel common and rare susceptibility loci for type 2 diabetes
由: Zeggini, E, et al.
出版: (2008)

Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes.
由: Gloyn, A, et al.
出版: (2003)