Induction of multifunctional human immunodeficiency virus type 1 (HIV-1)-specific T cells capable of proliferation in healthy subjects by using a prime-boost regimen of DNA- and modified vaccinia virus Ankara-vectored vaccines expressing HIV-1 Gag coupled to CD8+ T-cell epitopes.

A double-blind randomized phase I trial was conducted in human immunodeficiency virus type 1 (HIV-1)-negative subjects receiving vaccines vectored by plasmid DNA and modified vaccinia virus Ankara (MVA) expressing HIV-1 p24/p17 gag linked to a string of CD8(+) T-cell epitopes. The trial had two grou...

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Bibliographic Details
Main Authors:	Goonetilleke, N, Moore, S, Dally, L, Winstone, N, Cebere, I, Mahmoud, A, Pinheiro, S, Gillespie, G, Brown, D, Loach, V, Roberts, J, Guimaraes-Walker, A, Hayes, P, Loughran, K, Smith, C, De Bont, J, Verlinde, C, Vooijs, D, Schmidt, C, Boaz, M, Gilmour, J, Fast, P, Dorrell, L, Hanke, T, Mcmichael, A
Format:	Journal article
Language:	English
Published:	2006

Induction of multifunctional human immunodeficiency virus type 1 (HIV-1)-specific T cells capable of proliferation in healthy subjects by using a prime-boost regimen of DNA- and modified vaccinia virus Ankara-vectored vaccines expressing HIV-1 Gag coupled to CD8+ T-cell epitopes.

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