The T-box transcription factor Eomesodermin governs haemogenic competence of yolk sac mesodermal progenitors

Extra-embryonic mesoderm (ExM)-composed of the earliest cells that traverse the primitive streak-gives rise to the endothelium as well as haematopoietic progenitors in the developing yolk sac. How a specific subset of ExM becomes committed to a haematopoietic fate remains unclear. Here we demonstrat...

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Main Authors: Harland, LTG, Simon, CS, Senft, AD, Costello, I, Greder, L, Imaz-Rosshandler, I, Göttgens, B, Marioni, JC, Bikoff, EK, Porcher, C, de Bruijn, MFTR, Robertson, EJ
格式: Journal article
語言:English
出版: Springer Nature 2021