Synergy between variant PRC1 complexes defines polycomb-mediated gene repression

The Polycomb system modifies chromatin and plays an essential role in repressing gene expression to control normal mammalian development. However, the components and mechanisms that define how Polycomb protein complexes achieve this remain enigmatic. Here, we use combinatorial genetic perturbation c...

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Hlavní autoři: Fursova, NA, Blackledge, NP, Nakayama, M, Ito, S, Koseki, Y, Farcas, AM, King, HW, Koseki, H, Klose, RJ
Médium: Journal article
Jazyk:English
Vydáno: Cell Press 2019