A single molecule assay to probe monovalent and multivalent bonds between hyaluronan and its key leukocyte receptor CD44 under force

Glycosaminoglycans (GAGs), a category of linear, anionic polysaccharides, are ubiquitous in the extracellular space, and important extrinsic regulators of cell function. Despite the recognized significance of mechanical stimuli in cellular communication, however, only few single molecule methods are...

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Bibliographic Details
Main Authors: Bano, F, Banerji, S, Howarth, M, Jackson, D, Richter, R
Format: Journal article
Language:English
Published: Nature Publishing Group 2016