Long noncoding RNAs CUPID1 and CUPID2 mediate breast cancer risk at 11q13 by modulating the response to DNA damage
Breast cancer risk is strongly associated with an intergenic region on 11q13. We have previously shown that the strongest risk-associated SNPs fall within a distal enhancer that regulates CCND1. Here, we report that, in addition to regulating CCND1, this enhancer regulates two estrogen-regulated lon...
| Главные авторы: | , , , |
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| Формат: | Journal article |
| Язык: | English |
| Опубликовано: |
Elsevier
2017
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| _version_ | 1826304671736659968 |
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| author | Betts, JA Marjaneh, M Al-Ejeh, F Clark, MB |
| author_facet | Betts, JA Marjaneh, M Al-Ejeh, F Clark, MB |
| author_sort | Betts, JA |
| collection | OXFORD |
| description | Breast cancer risk is strongly associated with an intergenic region on 11q13. We have previously shown that the strongest risk-associated SNPs fall within a distal enhancer that regulates CCND1. Here, we report that, in addition to regulating CCND1, this enhancer regulates two estrogen-regulated long noncoding RNAs, CUPID1 and CUPID2. We provide evidence that the risk-associated SNPs are associated with reduced chromatin looping between the enhancer and the CUPID1 and CUPID2 bidirectional promoter. We further show that CUPID1 and CUPID2 are predominantly expressed in hormone-receptor-positive breast tumors and play a role in modulating pathway choice for the repair of double-strand breaks. These data reveal a mechanism for the involvement of this region in breast cancer. |
| first_indexed | 2024-03-07T06:21:21Z |
| format | Journal article |
| id | oxford-uuid:f2d100c8-df09-4477-87dd-08e946e89cd7 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:21:21Z |
| publishDate | 2017 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:f2d100c8-df09-4477-87dd-08e946e89cd72022-03-27T12:06:58ZLong noncoding RNAs CUPID1 and CUPID2 mediate breast cancer risk at 11q13 by modulating the response to DNA damageJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f2d100c8-df09-4477-87dd-08e946e89cd7EnglishSymplectic Elements at OxfordElsevier2017Betts, JAMarjaneh, MAl-Ejeh, FClark, MBBreast cancer risk is strongly associated with an intergenic region on 11q13. We have previously shown that the strongest risk-associated SNPs fall within a distal enhancer that regulates CCND1. Here, we report that, in addition to regulating CCND1, this enhancer regulates two estrogen-regulated long noncoding RNAs, CUPID1 and CUPID2. We provide evidence that the risk-associated SNPs are associated with reduced chromatin looping between the enhancer and the CUPID1 and CUPID2 bidirectional promoter. We further show that CUPID1 and CUPID2 are predominantly expressed in hormone-receptor-positive breast tumors and play a role in modulating pathway choice for the repair of double-strand breaks. These data reveal a mechanism for the involvement of this region in breast cancer. |
| spellingShingle | Betts, JA Marjaneh, M Al-Ejeh, F Clark, MB Long noncoding RNAs CUPID1 and CUPID2 mediate breast cancer risk at 11q13 by modulating the response to DNA damage |
| title | Long noncoding RNAs CUPID1 and CUPID2 mediate breast cancer risk at 11q13 by modulating the response to DNA damage |
| title_full | Long noncoding RNAs CUPID1 and CUPID2 mediate breast cancer risk at 11q13 by modulating the response to DNA damage |
| title_fullStr | Long noncoding RNAs CUPID1 and CUPID2 mediate breast cancer risk at 11q13 by modulating the response to DNA damage |
| title_full_unstemmed | Long noncoding RNAs CUPID1 and CUPID2 mediate breast cancer risk at 11q13 by modulating the response to DNA damage |
| title_short | Long noncoding RNAs CUPID1 and CUPID2 mediate breast cancer risk at 11q13 by modulating the response to DNA damage |
| title_sort | long noncoding rnas cupid1 and cupid2 mediate breast cancer risk at 11q13 by modulating the response to dna damage |
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