The mini-driver model of polygenic cancer evolution.

Much of cancer genetics research has focused on the identification of the most-important somatic mutations ('major drivers') that cause tumour growth. However, many mutations found in cancer might not be major drivers or 'passenger' mutations, but instead might have relatively we...

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Autori principali: Castro-Giner, F, Ratcliffe, P, Tomlinson, I
Natura: Journal article
Lingua:English
Pubblicazione: Nature Publishing Group 2015