Effect of graft perfusion with two CD45 monoclonal antibodies on incidence of kidney allograft rejection.

Effect of graft perfusion with two CD45 monoclonal antibodies on incidence of kidney allograft rejection.

In a blind trial, 77 patients were randomised to receive first cadaver kidney allografts that had been perfused either with a pair of CD45 monoclonal antibodies (mAbs), in an attempt to reduce the immunogenicity of passenger leucocytes, or with control human albumin solution. No complications of mAb...

詳細記述

書誌詳細
主要な著者: Brewer, Y, Palmer, A, Taube, D, Welsh, K, Bewick, M, Bindon, C, Hale, G, Waldmann, H, Dische, F, Parsons, V
フォーマット: Journal article
言語:English
出版事項: 1989
その他の書誌記述
要約:In a blind trial, 77 patients were randomised to receive first cadaver kidney allografts that had been perfused either with a pair of CD45 monoclonal antibodies (mAbs), in an attempt to reduce the immunogenicity of passenger leucocytes, or with control human albumin solution. No complications of mAb perfusion were observed. Patient and allograft survival were similar in both groups. Rejection episodes were recorded in 7 (18%) of the patient with mAb perfused allografts compared with 24 (63%) of the controls.

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