Effect of graft perfusion with two CD45 monoclonal antibodies on incidence of kidney allograft rejection.

In a blind trial, 77 patients were randomised to receive first cadaver kidney allografts that had been perfused either with a pair of CD45 monoclonal antibodies (mAbs), in an attempt to reduce the immunogenicity of passenger leucocytes, or with control human albumin solution. No complications of mAb...

Mô tả đầy đủ

Chi tiết về thư mục
Những tác giả chính: Brewer, Y, Palmer, A, Taube, D, Welsh, K, Bewick, M, Bindon, C, Hale, G, Waldmann, H, Dische, F, Parsons, V
Định dạng: Journal article
Ngôn ngữ:English
Được phát hành: 1989
Miêu tả
Tóm tắt:In a blind trial, 77 patients were randomised to receive first cadaver kidney allografts that had been perfused either with a pair of CD45 monoclonal antibodies (mAbs), in an attempt to reduce the immunogenicity of passenger leucocytes, or with control human albumin solution. No complications of mAb perfusion were observed. Patient and allograft survival were similar in both groups. Rejection episodes were recorded in 7 (18%) of the patient with mAb perfused allografts compared with 24 (63%) of the controls.