Targeting bromodomains: epigenetic readers of lysine acetylation.

Lysine acetylation is a key mechanism that regulates chromatin structure; aberrant acetylation levels have been linked to the development of several diseases. Acetyl-lysine modifications create docking sites for bromodomains, which are small interaction modules found on diverse proteins, some of whi...

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Bibliographic Details
Main Authors: Filippakopoulos, P, Knapp, S
Format: Journal article
Language:English
Published: 2014