Evaluation of Aspergillus niger as host for virus-like particle production, using the hepatitis B surface antigen as a model.
The filamentous fungus Aspergillus niger was transformed with the hepatitis B virus S gene encoding the major viral envelope protein under control of the constitutive A. nidulans glyceraldehyde-3-phosphate dehydrogenase ( gpdA) promoter. Approximately seven copies of the expression cassette were int...
| Autori principali: | , |
|---|---|
| Natura: | Journal article |
| Lingua: | English |
| Pubblicazione: |
2003
|