Human MAIT and CD8αα cells develop from a pool of type-17 precommitted CD8+ T cells.

Human mucosal associated invariant T (MAIT) CD8(+) and Tc17 cells are important tissue-homing cell populations, characterized by high expression of CD161 ((++)) and type-17 differentiation, but their origins and relationships remain poorly defined. By transcriptional and functional analyses, we demo...

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Hlavní autoři:	Walker, L, Kang, Y, Smith, M, Tharmalingham, H, Ramamurthy, N, Fleming, V, Sahgal, N, Leslie, A, Oo, Y, Geremia, A, Scriba, T, Hanekom, W, Lauer, G, Lantz, O, Adams, D, Powrie, F, Barnes, E, Klenerman, P
Médium:	Journal article
Jazyk:	English
Vydáno:	2012

Human MAIT and CD8αα cells develop from a pool of type-17 precommitted CD8+ T cells.

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