Genetic insights into the hypoxia-inducible factor (HIF) pathway.

Genetic insights into the hypoxia-inducible factor (HIF) pathway.

The HIF system probably operates in all cells, in all metazoan organisms. The effects of genetic alterations in the main components of the pathway offer a very powerful way to delineate its function in normal biology and disease. With time it is likely that more subtle variations will be identified...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Kiriakidis, S, Esteban, M, Maxwell, P
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	2007

Eitemau Tebyg

Activation of hypoxia-inducible factor (HIF) pathway in varicose veins
gan: Lim, C, et al.
Cyhoeddwyd: (2011)

Targeting the hypoxia-inducible factor (HIF) pathway in cancer.
gan: Poon, E, et al.
Cyhoeddwyd: (2009)

Hypoxia. The role of hypoxia and HIF-dependent signalling events in rheumatoid arthritis.
gan: Muz, B, et al.
Cyhoeddwyd: (2009)

Hypoxia, hypoxia-inducible factors (HIF), HIF hydroxylases and oxygen sensing.
gan: Webb, J, et al.
Cyhoeddwyd: (2009)

Functional variation in the hypoxia-inducible factor (HIF) pathway in humans
gan: Petousi, N
Cyhoeddwyd: (2012)

THE HYPOXIA INDUCIBLE FACTOR (HIF) PATHWAY IN AML: THERAPEUTIC TARGETING
gan: Büşra Tuğçe Akman
Cyhoeddwyd: (2024-12-01)

Pathways of Hypoxia-Inducible Factor (HIF) in the Orchestration of Uterine Fibroids Development
gan: Maria Fedotova, et al.
Cyhoeddwyd: (2023-08-01)

Hypoxia-inducible factor pathway and diseases of the vascular wall
gan: Lim, C, et al.
Cyhoeddwyd: (2013)

Hypoxia-inducible factor pathway and diseases of the vascular wall.
gan: Lim, C, et al.
Cyhoeddwyd: (2013)

The Hypoxia-Inducible Factor (HIF) pathway in adipocytes: The role of HIF-2 in adipose inflammation and hypertrophic cardiomyopathy
gan: Zhong eYun, et al.
Cyhoeddwyd: (2015-03-01)

Increased activation of the hypoxia-inducible factor pathway in varicose veins
gan: Lim, C, et al.
Cyhoeddwyd: (2012)

Increased activation of the hypoxia-inducible factor pathway in varicose veins.
gan: Lim, C, et al.
Cyhoeddwyd: (2012)

Hypoxia and HIF pathway in cancer and the placenta
gan: Macklin, P, et al.
Cyhoeddwyd: (2017)

Inhibition of hypoxia inducible factor (HIF) hydroxylases
gan: Conejo-Garcia, A, et al.
Cyhoeddwyd: (2005)

Factor inhibiting HIF (FIH-1) promotes renal cancer cell survival by protecting cells from HIF-1α-mediated apoptosis.
gan: Khan, M, et al.
Cyhoeddwyd: (2011)

Inhibition studies on hypoxia-inducible factor (HIF) hydroxylases
gan: Chan, M
Cyhoeddwyd: (2014)

Cardiopulmonary function in two human disorders of the hypoxia-inducible factor (HIF) pathway: von Hippel-Lindau disease and HIF-2α gain-of-function mutation.
gan: Formenti, F, et al.
Cyhoeddwyd: (2011)

Selection and analysis of a mutant cell line defective in the hypoxia-inducible factor-1 alpha-subunit (HIF-1alpha). Characterization of hif-1alpha-dependent and -independent hypoxia-inducible gene expression.
gan: Wood, S, et al.
Cyhoeddwyd: (1998)

The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages.
gan: Talks, K, et al.
Cyhoeddwyd: (2000)

Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.
gan: Raval, R, et al.
Cyhoeddwyd: (2005)

Genome-wide association of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha DNA binding with expression profiling of hypoxia-inducible transcripts.
gan: Mole, D, et al.
Cyhoeddwyd: (2009)

Kinetic investigations of the oxygen entry pathway of the hypoxia-inducible factor (HIF) prolyl hydroxylase 2
gan: Kearney, L
Cyhoeddwyd: (2015)

Genetic analysis of the role of the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH) in regulating hypoxia-inducible factor (HIF) transcriptional target genes [corrected].
gan: Stolze, I, et al.
Cyhoeddwyd: (2004)

Predominant role of hypoxia-inducible transcription factor (Hif)-1alpha versus Hif-2alpha in regulation of the transcriptional response to hypoxia.
gan: Sowter, H, et al.
Cyhoeddwyd: (2003)

Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha.
gan: Elkins, J, et al.
Cyhoeddwyd: (2003)

Studies on the inhibition of human hypoxia inducible factor (HIF) hydroxylases
gan: Yeoh, KK
Cyhoeddwyd: (2012)

Regulation of the Hypoxia-Inducible Factor (HIF) by Pro-Inflammatory Cytokines
gan: Mykyta I. Malkov, et al.
Cyhoeddwyd: (2021-09-01)

Hypoxia inducible factor (HIF) activity reporter cell line
gan: Shafee, Norazizah, et al.
Cyhoeddwyd: (2012)

Induction of KSHV latency-associated nuclear antigen (LANA) by hypoxia and hypoxia-inducible factors (HIF)
gan: Veeranna Ravindra P, et al.
Cyhoeddwyd: (2012-04-01)

Protein Hydroxylation by Hypoxia-Inducible Factor (HIF) Hydroxylases: Unique or Ubiquitous?
gan: Moritz J. Strowitzki, et al.
Cyhoeddwyd: (2019-04-01)

Targeting Hypoxia-Inducible Factor-1 (HIF-1) in Cancer: Emerging Therapeutic Strategies and Pathway Regulation
gan: Reem A. Qannita, et al.
Cyhoeddwyd: (2024-02-01)

Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family.
gan: Hewitson, K, et al.
Cyhoeddwyd: (2002)

A Comprehensive Review on Environmental and Microenvironmental Oxygen Sensing Pathways Mediated by Hypoxia-Inducible Factors (HIFs)
gan: Fatemeh Choopani, et al.
Cyhoeddwyd: (2019-06-01)

Mutation analysis of hypoxia-inducible factors HIF1A and HIF2A in renal cell carcinoma.
gan: Morris, MR, et al.
Cyhoeddwyd: (2009)

Expression of angiogenic factors and hypoxia inducible factors HIF 1, HIF 2 and CA IX in non-Hodgkin's lymphoma.
gan: Stewart, M, et al.
Cyhoeddwyd: (2002)

Hypoxia, hypoxia-inducible factor (HIF) and bone homeostasis: focus on osteoclast-mediated bone resorption
gan: Knowles, H
Cyhoeddwyd: (2015)

Role of hypoxia-inducible factor-1 (HIF-1) is angiogenesis and tumour biology
gan: Ratcliffe, P
Cyhoeddwyd: (1999)

Activation of the HIF pathway in cancer.
gan: Maxwell, P, et al.
Cyhoeddwyd: (2001)

Hypoxia-Inducible Factor-1 (Hif-1) in Experimental Brain Ischemia
gan: Rainald Schmidt-Kastner, et al.
Cyhoeddwyd: (2002-01-01)

The HIF-1 hypoxia-inducible factor modulates lifespan in C. elegans.
gan: Yi Zhang, et al.
Cyhoeddwyd: (2009-07-01)