Functional consequences of a polymorphism affecting NF-kappaB p50-p50 binding to the TNF promoter region.

Functional consequences of a polymorphism affecting NF-kappaB p50-p50 binding to the TNF promoter region.

Stimulation of the NF-kappaB pathway often causes p65-p50 and p50-p50 dimers to be simultaneously present in the cell nucleus. A natural polymorphism at nucleotide -863 in the human TNF promoter (encoding tumor necrosis factor [TNF]) region provides an opportunity to dissect the functional interacti...

Full beskrivning

Bibliografiska uppgifter
Huvudupphovsmän:	Udalova, I, Richardson, A, Denys, A, Smith, C, Ackerman, H, Foxwell, B, Kwiatkowski, D
Materialtyp:	Journal article
Språk:	English
Publicerad:	2000

Liknande verk

Association of accelerated erosive rheumatoid arthritis with a polymorphism that alters NF-kappaB binding to the TNF promoter region.
av: Udalova, I, et al.
Publicerad: (2002)

Comparing the fine specificity of DNA binding by NF-kappaB p50 and p52 using principal coordinates analysis.
av: Nijnik, A, et al.
Publicerad: (2003)

NF-kappaB-inducing kinase is dispensable for activation of NF-kappaB in inflammatory settings but essential for lymphotoxin beta receptor activation of NF-kappaB in primary human fibroblasts.
av: Smith, C, et al.
Publicerad: (2001)

Activation of NF-kappaB by the intracellular expression of NF-kappaB-inducing kinase acts as a powerful vaccine adjuvant.
av: Andreakos, E, et al.
Publicerad: (2006)

Rac mediates TNF-induced cytokine production via modulation of NF-kappaB.
av: Williams, L, et al.
Publicerad: (2008)

Interaction of AP-1 with a cluster of NF-kappa B binding elements in the human TNF promoter region.
av: Udalova, I, et al.
Publicerad: (2001)

Direct evidence for involvement of NF-kappaB in transcriptional activation of tumor necrosis factor by a spirochetal lipoprotein.
av: Udalova, I, et al.
Publicerad: (2000)

Complex NF-kappaB interactions at the distal tumor necrosis factor promoter region in human monocytes.
av: Udalova, I, et al.
Publicerad: (1998)

Is NF-kappaB a useful therapeutic target in rheumatoid arthritis?
av: Feldmann, M, et al.
Publicerad: (2002)

VEGF expression in human macrophages is NF-kappaB-dependent: studies using adenoviruses expressing the endogenous NF-kappaB inhibitor IkappaBalpha and a kinase-defective form of the IkappaB kinase 2.
av: Kiriakidis, S, et al.
Publicerad: (2003)

VEGF expression in human macrophages is NF-kappaB-dependent: studies using adenoviruses expressing the endogenous NF-kappaB inhibitor IkappaBalpha and a kinase-defective form of the IkappaB kinase 2.
av: Kiriakidis, S, et al.
Publicerad: (2003)

Two modes of transcriptional activation at native promoters by NF-kappaB p65.
av: Dominic van Essen, et al.
Publicerad: (2009-03-01)

Antigen-specific T-cell downregulation by human dendritic cells following blockade of NF-kappaB.
av: Calder, V, et al.
Publicerad: (2003)

NF-kappaB mediates tumor necrosis factor alpha-induced expression of optineurin, a negative regulator of NF-kappaB.
av: Cherukuri Sudhakar, et al.
Publicerad: (2009-01-01)

IKKalpha and IKKbeta each function to regulate NF-kappaB activation in the TNF-induced/canonical pathway.
av: Mazhar Adli, et al.
Publicerad: (2010-02-01)

Addressing reported pro-apoptotic functions of NF-kappaB: targeted inhibition of canonical NF-kappaB enhances the apoptotic effects of doxorubicin.
av: Brian K Bednarski, et al.
Publicerad: (2009-09-01)

Bacterial effector binding to ribosomal protein s3 subverts NF-kappaB function.
av: Xiaofei Gao, et al.
Publicerad: (2009-12-01)

Detecting and modulating the NF-kB activity in human immune cells: generation of human cell lines with altered levels of NF-kappaB.
av: Goh, F, et al.
Publicerad: (2009)

Visualization of lymphatic vessels through NF-kappaB activity.
av: Saban, MR, et al.
Publicerad: (2004)

NF-kappaB Signaling in Chronic Inflammatory Airway Disease
av: Michael Schuliga
Publicerad: (2015-06-01)

Compartimentalized NF-kappaB activity in the axon initial segment
av: Prehn Jochen, et al.
Publicerad: (2007-03-01)

Hsc70 is a novel interactor of NF-kappaB p65 in living hippocampal neurons.
av: Christin Klenke, et al.
Publicerad: (2013-01-01)

The flavonoid luteolin worsens chemical-induced colitis in NF-kappaB(EGFP) transgenic mice through blockade of NF-kappaB-dependent protective molecules.
av: Thomas Karrasch, et al.
Publicerad: (2007-07-01)

Evidence for a dual mechanism for IL-10 suppression of TNF-alpha production that does not involve inhibition of p38 mitogen-activated protein kinase or NF-kappa B in primary human macrophages.
av: Denys, A, et al.
Publicerad: (2002)

RelB/p50 regulates TNF production in LPS-stimulated dendritic cells and macrophages.
av: Gasparini, C, et al.
Publicerad: (2013)

RelB/p50 regulates TNF production in LPS-stimulated dendritic cells and macrophages
av: Gasparini, C, et al.
Publicerad: (2013)

Inflammatory bowel disease is associated with functional TNF polymorphism affecting OCT1/NF-kappa B interaction
av: van Heel, D, et al.
Publicerad: (2002)

A novel mechanism for TNF-alpha regulation by p38 MAPK: involvement of NF-kappa B with implications for therapy in rheumatoid arthritis.
av: Campbell, J, et al.
Publicerad: (2004)

Effective antigen presentation by dendritic cells is NF-kappaB dependent: coordinate regulation of MHC, co-stimulatory molecules and cytokines.
av: Yoshimura, S, et al.
Publicerad: (2001)

ERK, p38 AND NF-kappaB SIGNALING IN MONOCYTE DERIVED DENDRITIC CELLS IN PATIENTS WITH MYELODYSPLASTIC SYNDROME.
av: Ilina Micheva, et al.
Publicerad: (2014-12-01)

Haploid reporter screens aimed at identification of NF-kappaB regulators
av: Lee, Clarissa Ci
Publicerad: (2014)

Memory extinction entails the inhibition of the transcription factor NF-kappaB.
av: Emiliano Merlo, et al.
Publicerad: (2008-01-01)

NF-kappaB/Rel-mediated regulation of the neural fate in Drosophila.
av: Savita Ayyar, et al.
Publicerad: (2007-11-01)

Neuroadaptations in human chronic alcoholics: dysregulation of the NF-kappaB system.
av: Anna Okvist, et al.
Publicerad: (2007-09-01)

Interplay of Murine Gammaherpesvirus 68 with NF-kappaB Signaling of the Host
av: Laurie T Krug, et al.
Publicerad: (2016-08-01)

TNFalpha-induced macrophage chemokine secretion is more dependent on NF-kappaB expression than lipopolysaccharides-induced macrophage chemokine secretion.
av: Ciesielski, C, et al.
Publicerad: (2002)

The toll-like receptor-nuclear factor kappaB pathway in rheumatoid arthritis.
av: Andreakos, E, et al.
Publicerad: (2005)

Unraveling regulatory programs for NF-kappaB, p53 and microRNAs in head and neck squamous cell carcinoma.
av: Bin Yan, et al.
Publicerad: (2013-01-01)

IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer.
av: Gyrd-Hansen, M, et al.
Publicerad: (2010)

Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB.
av: Brummelkamp, T, et al.
Publicerad: (2003)