Functional consequences of a polymorphism affecting NF-kappaB p50-p50 binding to the TNF promoter region.

Functional consequences of a polymorphism affecting NF-kappaB p50-p50 binding to the TNF promoter region.

Stimulation of the NF-kappaB pathway often causes p65-p50 and p50-p50 dimers to be simultaneously present in the cell nucleus. A natural polymorphism at nucleotide -863 in the human TNF promoter (encoding tumor necrosis factor [TNF]) region provides an opportunity to dissect the functional interacti...

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Bibliographic Details
Main Authors:	Udalova, I, Richardson, A, Denys, A, Smith, C, Ackerman, H, Foxwell, B, Kwiatkowski, D
Format:	Journal article
Language:	English
Published:	2000

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