T-cell- and macrophage-mediated axon damage in the absence of a CNS-specific immune response: involvement of metalloproteinases.

Recent evidence has highlighted the fact that axon injury is an important component of multiple sclerosis pathology. The issue of whether a CNS antigen-specific immune response is required to produce axon injury remains unresolved. We investigated the extent and time course of axon injury in a roden...

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Bibliographic Details
Main Authors: Newman, T, Woolley, S, Hughes, P, Sibson, N, Anthony, D, Perry, V
Format: Journal article
Language:English
Published: 2001