"cAMP sponge": a buffer for cyclic adenosine 3', 5'-monophosphate

BACKGROUND: While intracellular buffers are widely used to study calcium signaling, no such tool exists for the other major second messenger, cyclic AMP (cAMP). METHODS/PRINCIPAL FINDINGS: Here we describe a genetically encoded buffer for cAMP based on the high-affinity cAMP-binding carboxy-terminu...

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Detalles Bibliográficos
Main Authors: Lefkimmiatis, K, Moyer, M, Curci, S, Hofer, A
Formato: Journal article
Idioma:English
Publicado: Public Library of Science 2009