A dynamic CD2 rich compartment at the outer edge of the immunological synapse boosts and integrates signals

The CD2–CD58 recognition system promotes adhesion and signaling and counters exhaustion in human T cells. We found that CD2 localized to the outer edge of the mature immunological synapse, with cellular or artificial APC, in a pattern we refer to as a ‘CD2 corolla’. The corolla captured engaged CD28...

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Váldodahkkit:	Demetriou, P, Abu-Shah, E, Valvo, S, McCuaig, S, Mayya, V, Kvalvaag, A, Starkey, T, Korobchevskaya, K, Lee, LYW, Friedrich, M, Mann, E, Kutuzov, MA, Morotti, M, Wietek, N, Rada, H, Yusuf, S, Afrose, J, Siokis, A, Meyer-Hermann, M, Ahmed, A, Depoil, D, Dustin, ML
Materiálatiipa:	Journal article
Giella:	English
Almmustuhtton:	Nature Research 2020

A dynamic CD2 rich compartment at the outer edge of the immunological synapse boosts and integrates signals

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