Insights into the activation mechanism of class I HDAC complexes by inositol phosphates
Histone deacetylases (HDACs) 1, 2 and 3 form the catalytic subunit of several large transcriptional repression complexes. Unexpectedly, the enzymatic activity of HDACs in these complexes has been shown to be regulated by inositol phosphates, which bind in a pocket sandwiched between the HDAC and co-...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal article |
| Published: |
Nature Publishing Group
2016
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