Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases.
The polytopic membrane protein Rhomboid-1 promotes the cleavage of the membrane-anchored TGFalpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Until now, the mechanism of this key signaling regulator has been obscure, but our analysis suggests that Rhomboid-1 is a n...
| Główni autorzy: | , , |
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| Format: | Journal article |
| Język: | English |
| Wydane: |
2001
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