A comparative cross-linking strategy to probe conformational changes in protein complexes.
Chemical cross-linking, together with mass spectrometry (MS), is a powerful combination for probing subunit interactions within static protein assemblies. To probe conformational changes in response to stimuli, we have developed a comparative cross-linking strategy, using lysine-specific deuterated...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Nature Publishing Group
2014
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