Foxp3 expression is required for the induction of therapeutic tissue tolerance.

CD4(+)Foxp3(+) regulatory T cells (Treg) are essential for immune homeostasis and maintenance of self-tolerance. They are produced in the thymus and also generated de novo in the periphery in a TGF-β-dependent manner. Foxp3(+) Treg are also required to achieve tolerance to transplanted tissues when...

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Bibliographic Details
Main Authors:	Regateiro, F, Chen, Y, Kendal, A, Hilbrands, R, Adams, E, Cobbold, S, Ma, J, Andersen, K, Betz, A, Zhang, M, Madhiwalla, S, Roberts, B, Waldmann, H, Nolan, K, Howie, D
Format:	Journal article
Language:	English
Published:	2012

Foxp3 expression is required for the induction of therapeutic tissue tolerance.

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