The molecular basis of Plasmodium falciparum merozoite invasion inhibition via anti-PfCyRPA antibodies

The molecular basis of Plasmodium falciparum merozoite invasion inhibition via anti-PfCyRPA antibodies

<p><em>Plasmodium falciparum</em>, the pathogen responsible for the deadliest form of malaria, continues to exact an immense human toll, disproportionality shouldered by countries in sub-Saharan Africa. Significant progress has been made this century in reducing global malaria mort...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awdur:	Ragotte, R
Awduron Eraill:	Draper, S
Fformat:	Traethawd Ymchwil
Iaith:	English
Cyhoeddwyd:	2020
Pynciau:	Immunology Biochemistry Monoclonal antibodies Malaria

Eitemau Tebyg

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Expanding the Malaria Antibody Toolkit: Development and Characterisation of Plasmodium falciparum RH5, CyRPA, and CSP Recombinant Human Monoclonal Antibodies
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Structural basis for inhibition of erythrocyte invasion by antibodies to Plasmodium falciparum protein CyRPA
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The essential malaria protein PfCyRPA targets glycans to invade erythrocytes
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Identification and characterisation of candidate monoclonal antibody Ebolavirus therapeutics
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Generation and characterisation of monoclonal antibodies specific to Plasmodium falciparum enolase
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Antibodies targeting the PfRH1 binding domain inhibit invasion of Plasmodium falciparum merozoites.
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Identification of a Novel RAMA/RON3 Rhoptry Protein Complex in Plasmodium falciparum Merozoites
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Plasmodium falciparum merozoite invasion is inhibited by antibodies that target the PfRh2a and b binding domains.
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Framework for Characterizing Longitudinal Antibody Response in Children After Plasmodium falciparum Infection
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A Molecular Analysis of Memory B Cell and Antibody Responses Against Plasmodium falciparum Merozoite Surface Protein 1 in Children and Adults From Uganda
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Characterization of a novel Plasmodium falciparum merozoite surface antigen and potential vaccine target
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Therapeutic monoclonal antibody for Sporotrichosis
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Standardization and validation of a cytometric bead assay to assess antibodies to multiple <it>Plasmodium falciparum</it> recombinant antigens
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Process development and preclinical evaluation of a major Plasmodium falciparum blood stage vaccine candidate, Cysteine-Rich Protective Antigen (CyRPA)
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