Mouse models of β-cell K channel dysfunction
ATP-sensitive K (K) channels in pancreatic β-cells couple glucose metabolism to insulin secretion. Reduced K channel activity produces excessive insulin release and hyperinsulinism whereas increased K channel activity leads to lower insulin secretion and diabetes. Paradoxically, mice with genetic de...
| Main Authors: | , |
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| Format: | Journal article |
| Published: |
2013
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