Mouse models of β-cell K channel dysfunction

Mouse models of β-cell K channel dysfunction

ATP-sensitive K (K) channels in pancreatic β-cells couple glucose metabolism to insulin secretion. Reduced K channel activity produces excessive insulin release and hyperinsulinism whereas increased K channel activity leads to lower insulin secretion and diabetes. Paradoxically, mice with genetic de...

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Sonraí bibleagrafaíochta
Príomhchruthaitheoirí:	Brereton, M, Ashcroft, F
Formáid:	Journal article
Foilsithe / Cruthaithe:	2013

Míreanna comhchosúla

β-Cell dysfunction in diabetes: a crisis of identity?
de réir: Brereton, M, et al.
Foilsithe / Cruthaithe: (2016)

Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells
de réir: Brereton, M, et al.
Foilsithe / Cruthaithe: (2016)

Effects of internal chloride on ATP-sensitive K-channels in mouse pancreatic beta-cells.
de réir: Takano, M, et al.
Foilsithe / Cruthaithe: (1994)

THE EFFECT OF INTRACELLULAR PROTONS ON ATP-SENSITIVE K+ CHANNELS IN MOUSE PANCREATIC BETA-CELLS
de réir: Proks, P, et al.
Foilsithe / Cruthaithe: (1993)

Effects of intracellular pH on ATP-sensitive K+ channels in mouse pancreatic beta-cells.
de réir: Proks, P, et al.
Foilsithe / Cruthaithe: (1994)

THE EFFECT OF INTRACELLULAR PH ON ATP-SENSITIVE K+ CHANNELS IN ISOLATED MOUSE PANCREATIC BETA-CELLS
de réir: Proks, P, et al.
Foilsithe / Cruthaithe: (1993)

Is type 2 diabetes a glycogen storage disease of pancreatic β cells?
de réir: Ashcroft, F, et al.
Foilsithe / Cruthaithe: (2017)

ATP-REGULATED K CHANNELS MODULATE ELECTRICAL-ACTIVITY IN MOUSE ISOLATED PANCREATIC BETA-CELLS
de réir: Ashcroft, F, et al.
Foilsithe / Cruthaithe: (1990)

BLOCK OF ATP-SENSITIVE K+ CHANNELS IN ISOLATED MOUSE PANCREATIC BETA-CELLS BY 2,3-BUTANEDIONE MONOXIME
de réir: Smith, P, et al.
Foilsithe / Cruthaithe: (1993)

Block of ATP-sensitive K+ channels in isolated mouse pancreatic beta-cells by 2,3-butanedione monoxime.
de réir: Smith, P, et al.
Foilsithe / Cruthaithe: (1994)

Aβ-mediated nuclear pore complex dysfunction in a mouse model of alzheimer's disease
de réir: Vibhavari, Bansal
Foilsithe / Cruthaithe: (2023)

Characterisation of K+ channels in human fetoplacental vascular smooth muscle cells
de réir: Brereton, M, et al.
Foilsithe / Cruthaithe: (2013)

Single Ca channel currents in mouse pancreatic B-cells.
de réir: Rorsman, P, et al.
Foilsithe / Cruthaithe: (1988)

SINGLE CALCIUM-CHANNEL CURRENTS IN MOUSE PANCREATIC B-CELLS
de réir: Ashcroft, F, et al.
Foilsithe / Cruthaithe: (1988)

SINGLE CALCIUM-CHANNEL ACTIVITY IN MOUSE PANCREATIC BETA-CELLS
de réir: Ashcroft, F, et al.
Foilsithe / Cruthaithe: (1989)

Single calcium channel activity in mouse pancreatic beta-cells.
de réir: Ashcroft, F, et al.
Foilsithe / Cruthaithe: (1989)

RUNDOWN OF ATP-SENSITIVE K-CURRENTS IN MOUSE PANCREATIC BETA-CELLS
de réir: Williams, B, et al.
Foilsithe / Cruthaithe: (1992)

CHARACTERIZATION OF AN INWARDLY RECTIFYING K+ CHANNEL EXPRESSED IN PANCREATIC BETA-CELLS
de réir: Ashcroft, F
Foilsithe / Cruthaithe: (1995)

Cardiac dysfunction and metabolic inflexibility in a mouse model of diabetes without dyslipidaemia
de réir: Rohm, M, et al.
Foilsithe / Cruthaithe: (2018)

The Ba2+ block of the ATP-sensitive K+ current of mouse pancreatic beta-cells.
de réir: Takano, M, et al.
Foilsithe / Cruthaithe: (1996)

Modification of K-ATP channels in pancreatic beta-cells by trypsin.
de réir: Proks, P, et al.
Foilsithe / Cruthaithe: (1993)

THE ROLE OF THE ATP-SENSITIVE K-CHANNEL IN STIMULUS-RESPONSE COUPLING IN THE PANCREATIC BETA-CELL
de réir: Ashcroft, S, et al.
Foilsithe / Cruthaithe: (1989)

Separate processes mediate nucleotide-induced inhibition and stimulation of the ATP-regulated K(+)-channels in mouse pancreatic beta-cells.
de réir: Bokvist, K, et al.
Foilsithe / Cruthaithe: (1991)

Heterogeneity of beta-cell secretion. Possible involvement of K-ATP channels.
de réir: Faehling, M, et al.
Foilsithe / Cruthaithe: (1997)

Properties and functions of ATP-sensitive K-channels.
de réir: Ashcroft, S, et al.
Foilsithe / Cruthaithe: (1990)

The ATP-sensitivity of K+ channels in rat pancreatic B-cells is modulated by ADP.
de réir: Kakei, M, et al.
Foilsithe / Cruthaithe: (1986)

A model for regulation of the beta-cell ATP-sensitive K+-channel by nucleotides and diazoxide.
de réir: Tucker, S, et al.
Foilsithe / Cruthaithe: (1997)

Modeling K(ATP) channel gating and its regulation.
de réir: Proks, P, et al.
Foilsithe / Cruthaithe: (2009)

Differential sensitivity of beta-cell and extrapancreatic K(ATP) channels to gliclazide.
de réir: Gribble, F, et al.
Foilsithe / Cruthaithe: (1999)

The Yin and Yang of the K(ATP) channel.
de réir: Ashcroft, F
Foilsithe / Cruthaithe: (2000)

ATP-SENSITIVE K-CHANNELS IN HIT-T15 INSULIN SECRETING CELLS
de réir: Kelly, R, et al.
Foilsithe / Cruthaithe: (1988)

Interaction of vanadate with the cloned beta cell K(ATP) channel.
de réir: Proks, P, et al.
Foilsithe / Cruthaithe: (1999)

Modulation of gating of the cloned beta-cell K-ATP channel
de réir: Proks, P, et al.
Foilsithe / Cruthaithe: (1998)

Expression of functionally active ATP-sensitive K-channels in insect cells using baculovirus.
de réir: Mikhailov, M, et al.
Foilsithe / Cruthaithe: (1998)

ATRX dysfunction induces replication defects in primary mouse cells
de réir: Clynes, D, et al.
Foilsithe / Cruthaithe: (2014)

The dependence on intracellular ATP concentration of ATP-sensitive K-channels and of Na,K-ATPase in intact HIT-T15 beta-cells.
de réir: Niki, I, et al.
Foilsithe / Cruthaithe: (1989)

High expression of trp, a putative calcium-release activated channel in mouse insulinoma cells
de réir: Sakura, H, et al.
Foilsithe / Cruthaithe: (1997)

Dual effects of Na-azide on the whole-cell K-ATP current in isolated mouse pancreatic beta-cells
de réir: Trapp, S, et al.
Foilsithe / Cruthaithe: (1997)

A touching case of channel regulation: the ATP-sensitive K+ channel.
de réir: Tucker, S, et al.
Foilsithe / Cruthaithe: (1998)

EFFECTS OF TRYPSIN ON ATP-DEPENDENT-K+ CHANNELS FROM PANCREATIC BETA-CELLS
de réir: Proks, P, et al.
Foilsithe / Cruthaithe: (1992)