Isoform-selective ATAD2 chemical probe with novel chemical structure and unusual mode of action

ATAD2 (ANCCA) is an epigenetic regulator and transcriptional cofactor, whose overexpression has been linked to the progress of various cancer types. Here, we report a DNA-encoded library screen leading to the discovery of BAY-850, a potent and isoform selective inhibitor that specifically induces AT...

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Bibliographic Details
Main Authors:	Fernández-Montalván, A, Berger, M, Kuropka, B, Koo, S, Badock, V, Weiske, J, Puetter, V, Holton, S, Stöckigt, D, Ter Laak, A, Centrella, P, Clark, M, Dumelin, C, Sigel, E, Soutter, H, Troast, D, Zhang, Y, Cuozzo, J, Keefe, A, Roche, D, Rodeschini, V, Chaikuad, A, Díaz-Sáez, L, Bennett, J, Fedorov, O, Huber, K, Hübner, J, Weinmann, H, Hartung, I, Gorjánácz, M
Format:	Journal article
Language:	English
Published:	American Chemical Society 2017

Isoform-selective ATAD2 chemical probe with novel chemical structure and unusual mode of action

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