A mutation in Af4 is predicted to cause cerebellar ataxia and cataracts in the robotic mouse.

A mutation in Af4 is predicted to cause cerebellar ataxia and cataracts in the robotic mouse.

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The robotic mouse is an autosomal dominant mutant that arose from a large-scale chemical mutagenesis program. It has a jerky, ataxic gait and develops adult-onset Purkinje cell loss in the cerebellum in a striking region-specific pattern, as well as cataracts. Genetic and physical mapping of the dis...

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Bibliografische gegevens
Hoofdauteurs: Isaacs, A, Oliver, P, Jones, E, Jeans, A, Potter, A, Hovik, B, Nolan, P, Vizor, L, Glenister, P, Simon, A, Gray, I, Spurr, N, Brown, S, Hunter, A, Davies, K
Formaat: Journal article
Taal:English
Gepubliceerd in: 2003

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