Structure of three tandem filamin domains reveals auto-inhibition of ligand binding.
Human filamins are large actin-crosslinking proteins composed of an N-terminal actin-binding domain followed by 24 Ig-like domains (IgFLNs), which interact with numerous transmembrane receptors and cytosolic signaling proteins. Here we report the 2.5 A resolution structure of a three-domain fragment...
Main Authors: | , , , , , , , |
---|---|
格式: | Journal article |
语言: | English |
出版: |
2007
|