Structure of three tandem filamin domains reveals auto-inhibition of ligand binding.
Human filamins are large actin-crosslinking proteins composed of an N-terminal actin-binding domain followed by 24 Ig-like domains (IgFLNs), which interact with numerous transmembrane receptors and cytosolic signaling proteins. Here we report the 2.5 A resolution structure of a three-domain fragment...
المؤلفون الرئيسيون: | Lad, Y, Kiema, T, Jiang, P, Pentikäinen, O, Coles, C, Campbell, I, Calderwood, D, Ylänne, J |
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التنسيق: | Journal article |
اللغة: | English |
منشور في: |
2007
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مواد مشابهة
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Structure of three tandem filamin domains reveals auto-inhibition of ligand binding
حسب: Lad, Y, وآخرون
منشور في: (2007) -
The molecular basis of filamin binding to integrins and competition with talin.
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Assembly of a filamin four-domain fragment and the influence of splicing variant-1 on the structure.
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Structural basis of the migfilin-filamin interaction and competition with integrin beta tails.
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Flexible Structure of Peptide-Bound Filamin A Mechanosensor Domain Pair 20-21.
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