Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.

Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.

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Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired β-cell function, raised glucose levels, insulin resistance, and type 2 diabetes (T2D). Studies of the insulin processing pathway could provide new insights about T2D pathophys...

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Bibliographic Details
Main Authors: Strawbridge, R, Dupuis, J, Prokopenko, I, Barker, A, Ahlqvist, E, Rybin, D, Petrie, JR, Travers, M, Bouatia-Naji, N, Dimas, A, Nica, A, Wheeler, E, Chen, H, Voight, B, Taneera, J, Kanoni, S, Peden, J, Turrini, F, Gustafsson, S, Zabena, C, Almgren, P, Barker, D, Barnes, D, Dennison, E, Eriksson, J
Format: Journal article
Language:English
Published: 2011

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