Comprehensive pharmacogenetic profiling of the epidermal growth factor receptor pathway for biomarkers of response to, and toxicity from, cetuximab

BACKGROUND:Somatic mutations in the epidermal growth factor receptor (EGFR) intracellular signalling pathways predict non-response to cetuximab in the treatment of advanced colorectal cancer (aCRC). We hypothesised that common germline variants within these pathways may also play similar roles. METH...

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Bibliographic Details
Main Authors:	Madi, A, Fisher, D, Maughan, TS, Colley, JP, Meade, AM, Tejpar, S, Van Den Bosch, B, Maynard, J, Humphreys, V, Wasan, H, Adams, RA, Idziaszczyk, S, Harris, R, Kaplan, RS, Cheadle, JP
Format:	Journal article
Language:	English
Published:	BMJ 2017

Comprehensive pharmacogenetic profiling of the epidermal growth factor receptor pathway for biomarkers of response to, and toxicity from, cetuximab

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