The importance of clinical importance when determining the target difference in sample size calculations

Recently, it was argued that clinically important differences should play no role in sample size calculations. Instead, it was proposed that sample size calculations should focus on setting realistic estimates of treatment benefit. We disagree, and argue in this article that considering the importan...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Parker, RA, Cook, JA
Format: Journal article
Sprache:English
Veröffentlicht: BioMed Central 2023