Synthesis of kinase inhibitors containing a pentafluorosulfanyl moiety

A series of 3-methylidene-1H-indol-2(3H)-ones substituted with a 5- or 6-pentafluorosulfanyl group has been synthesized by a Knoevenagel condensation reaction of SF5-substituted oxindoles with a range of aldehydes. The resulting products were characterized by X-ray crystallography studies and were t...

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Main Authors: Sansook, S, Ocasio, CA, Day, IJ, Tizzard, GJ, Coles, SJ, Fedorov, O, Bennett, JM, Elkins, JM, Spencer, J
格式: Journal article
语言:English
出版: Royal Society of Chemistry 2017