Regulation of intracellular pH in cancer cell lines under normoxia and hypoxia.

Acid-extrusion by active transport is important in metabolically active cancer cells, where it removes excess intracellular acid and sets the intracellular resting pH. Hypoxia is a major trigger of adaptive responses in cancer, but its effect on acid-extrusion remains unclear. We studied pH-regulati...

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Bibliographic Details
Main Authors: Hulikova, A, Harris, A, Vaughan-Jones, R, Swietach, P
Format: Journal article
Language:English
Published: 2013