MMP-13 is constitutively produced in human chondrocytes and co-endocytosed with ADAMTS-5 and TIMP-3 by the endocytic receptor LRP1

MMP-13 is constitutively produced in human chondrocytes and co-endocytosed with ADAMTS-5 and TIMP-3 by the endocytic receptor LRP1

Matrix metalloproteinase 13 (MMP-13) degrades collagenous extracellular matrix and its aberrant activity associates with diseases such as arthritis, cancer, atherosclerosis and fibrosis. The wide range of MMP-13 proteolytic capacity suggests that it is a powerful, potentially destructive proteinase...

Full description

Bibliographic Details
Main Authors:	Yamamoto, K, Okano, H, Miyagawa, W, Visse, R, Shitomi, Y, Santamaria, S, Dudhia, J, Troeberg, L, Strickland, D, Hirohata, S, Nagase, H
Format:	Journal article
Published:	Elsevier 2016

Similar Items

Low density lipoprotein receptor-related protein 1 (LRP1)-mediated endocytic clearance of a disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4): functional differences of non-catalytic domains of ADAMTS-4 and ADAMTS-5 in LRP1 binding.
by: Yamamoto, K, et al.
Published: (2014)

Investigation of the endocytic pathway of ADAMTS-4
by: Owen, K, et al.
Published: (2009)

LRP-dependent and -independent internalisation of TIMP-3
by: Scilabra, S, et al.
Published: (2011)

Cellular uptake of proMMP-2:TIMP-2 complexes by the endocytic receptor megalin/LRP-2
by: Manuel Johanns, et al.
Published: (2017-06-01)

Endocytic pathways of TIMP-3 and its N-terminal inhibitory domain
by: Scilabra, S, et al.
Published: (2009)

LRP-1-mediated endocytosis regulates extracellular activity of ADAMTS-5 in articular cartilage.
by: Yamamoto, K, et al.
Published: (2013)

The C-terminal domains of ADAMTS-4 and ADAMTS-5 promote association with N-TIMP-3.
by: Troeberg, L, et al.
Published: (2009)

Reactive-site mutants of N-TIMP-3 that selectively inhibit ADAMTS-4 and ADAMTS-5: biological and structural implications.
by: Lim, N, et al.
Published: (2010)

Development of a monoclonal anti-ADAMTS-5 antibody that specifically blocks the interaction with LRP1
by: Santamaria, S, et al.
Published: (2017)

Calcium pentosan polysulfate increases affinity between aggrecanases (ADAMTS-4 and-5) and TIMP-3 by a conformational change
by: Troeberg, L, et al.
Published: (2010)

Low density lipoprotein receptor-related protein mediates endocytic clearance of pro-MMP-2.TIMP-2 complex through a thrombospondin-independent mechanism.
by: Emonard, H, et al.
Published: (2004)

Analysis of TIMP expression and activity.
by: Troeberg, L, et al.
Published: (2007)

Pentosan polysulfate increases affinity between ADAMTS-5 and TIMP-3 through formation of an electrostatically driven trimolecular complex
by: Troeberg, L, et al.
Published: (2012)

Pentosan polysulfate increases affinity between ADAMTS-5 and TIMP-3 through formation of an electrostatically driven trimolecular complex.
by: Troeberg, L, et al.
Published: (2012)

Inhibition of LRP1 shedding reverses cartilage matrix degradation in osteoarthritis
by: Yamamoto, K, et al.
Published: (2017)

TIMP-3 inhibits the procollagen N-proteinase ADAMTS-2.
by: Wang, WM, et al.
Published: (2006)

Structure and function of matrix metalloproteinases and TIMPs.
by: Nagase, H, et al.
Published: (2006)

Dissecting the interaction between tissue inhibitor of metalloproteinases-3 (TIMP-3) and low density lipoprotein receptor-related protein-1 (LRP-1): Development of a "TRAP" to increase levels of TIMP-3 in the tissue.
by: Scilabra, S, et al.
Published: (2016)

E. coli expression of TIMP-4 and comparative kinetic studies with TIMP-1 and TIMP-2: insights into the interactions of TIMPs and matrix metalloproteinase 2 (gelatinase A).
by: Troeberg, L, et al.
Published: (2002)

Functional differences of the catalytic and non-catalytic domains in human ADAMTS-4 and ADAMTS-5 in aggrecanolytic activity.
by: Fushimi, K, et al.
Published: (2008)

Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) - Physiological roles and structural basis of MMP inhibition by TIMP-1
by: Nagase, H, et al.
Published: (2000)

Calcium pentosan polysulfate is a multi-functional aggrecanase inhibitor that enhances interaction with endogenous TIMP-3 in cartilage
by: Troeberg, L, et al.
Published: (2009)

Crystal structure of MT1-MMP hemopexin domain: identification of the dimer interface
by: Tochowicz, A, et al.
Published: (2010)

Differential inhibition of membrane type 3 (MT3)-matrix metalloproteinase (MMP) and MT1-MMP by tissue inhibitor of metalloproteinase (TIMP)-2 and TIMP-3 rgulates pro-MMP-2 activation.
by: Zhao, H, et al.
Published: (2004)

Expression of the metalloproteases MMP-1, MMP-2, MMP-3, MMP-9, MMP-11, TIMP-1 and TIMP-2 in angiocentric midfacial lymphomas
by: Roa Lourdes, et al.
Published: (2008-10-01)

Individual Timp deficiencies differentially impact pro-MMP-2 activation.
by: English, J, et al.
Published: (2006)

Role of MMP-2, MMP-9, TIMP-1, and TIMP-2 in children with ventricular septal defect
by: Nina Maric, et al.
Published: (2024-10-01)

Crystal structure of an active form of human MMP-1.
by: Iyer, S, et al.
Published: (2006)

Expressions of Matrix Metalloproteinases (MMP-2, MMP-7, and MMP-9) and Their Inhibitors (TIMP-1, TIMP-2) in Inflammatory Bowel Diseases
by: Katarzyna Jakubowska, et al.
Published: (2016-01-01)

Expression of matrix metalloproteinases (MMP-1, MMP-2 and MMP-9) and their inhibitors (TIMP-1 and TIMP-2) in oral submucous fibrosis
by: Rajendran R, et al.
Published: (2006-01-01)

The usefulness of MMP-9, TIMP-1 and MMP-9/TIMP-1 ratio for diagnosis and assessment of COPD severity
by: Sanja Dimic-Janjic, et al.
Published: (2023-03-01)

Involvement of ADAMTS5 and hyaluronidase in aggrecan degradation and release from OSM-stimulated cartilage.
by: Durigova, M, et al.
Published: (2011)

Involvement of ADAMTS5 and hyaluronidase in aggrecan degradation and release from OSM-stimulated cartilage
by: M Durigova, et al.
Published: (2011-01-01)

Generation of Tamoxifen inducible mice to express hTIMP-3 in articular chondrocytes to block degradation of cartilage in osteoarthritis
by: Lo Cascio, L, et al.
Published: (2012)

Evaluating the role of ADAMTS proteoglycanases and TIMP-3 in prostate cancer progression
by: Adeniji, O, et al.
Published: (2007)

Increased TIMP-3 expression alters the cellular secretome through dual inhibition of the metalloprotease ADAM10 and ligand-binding of the LRP-1 receptor
by: Scilabra, SD, et al.
Published: (2018)

Matrix metalloproteinase expression and function during fin regeneration in zebrafish: analysis of MT1-MMP, MMP2 and TIMP2.
by: Bai, S, et al.
Published: (2005)

Diagnostic values of MMP-7, MMP-9, MMP-11, TIMP-1, TIMP-2, CEA, and CA19-9 in patients with colorectal cancer
by: Xiwen Huang, et al.
Published: (2021-05-01)

MT1-MMP in human rheumatoid arthritis
by: Miller, M, et al.
Published: (2009)

Engineered tissue inhibitor of metalloproteinases-3 variants resistant to endocytosis have prolonged chondroprotective activity
by: Doherty, C, et al.
Published: (2016)