A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21.

We tested 310,605 SNPs for association in 778 individuals with celiac disease and 1,422 controls. Outside the HLA region, the most significant finding (rs13119723; P = 2.0 x 10(-7)) was in the KIAA1109-TENR-IL2-IL21 linkage disequilibrium block. We independently confirmed association in two further...

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Bibliographic Details
Main Authors:	van Heel, D, Franke, L, Hunt, K, Gwilliam, R, Zhernakova, A, Inouye, M, Wapenaar, M, Barnardo, M, Bethel, G, Holmes, G, Feighery, C, Jewell, D, Kelleher, D, Kumar, P, Travis, S, Walters, JR, Sanders, D, Howdle, P, Swift, J, Playford, R, McLaren, WM, Mearin, M, Mulder, C, McManus, R, McGinnis, R
Format:	Journal article
Language:	English
Published:	2007

A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21.

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